The Fc domain of antibodies is the part of the molecule that interacts with the immune system and mediates many of the functional activities of antibodies, including binding to Fc receptors on immune cells and regulation of antibody half-life. Yurogen offers the following Fc domain engineering services:
1. Fc domain swapping: switch the Fc region between species and/or antibody isotypes.
2. Site mutation of the Fc domain to change its interaction with Fc receptors.
3. Fusion of the Fc domain: Fuse the Fc domain with other proteins, such as cytokines.